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Biochim Biophys Acta. 2014 Jun;1842(6):798-801. doi: 10.1016/j.bbadis.2013.09.016. Epub 2013 Oct 24.

Stressing on the nucleolus in cardiovascular disease.

Author information

1
Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA.
2
Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA. Electronic address: heartman4ever@icloud.com.

Abstract

The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.

KEYWORDS:

Cardiovascular; Disease; Heart; Nucleolus

PMID:
24514103
PMCID:
PMC3972279
DOI:
10.1016/j.bbadis.2013.09.016
[Indexed for MEDLINE]
Free PMC Article

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