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Antimicrob Agents Chemother. 2014;58(4):2472-4. doi: 10.1128/AAC.02571-13. Epub 2014 Feb 10.

Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria.

Author information

1
Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.

Abstract

Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-β-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all aminoglycosides. All those isolates were clonally related and belonged to the same sequence type, ST101. In addition to being the first to identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.

PMID:
24514099
PMCID:
PMC4023783
DOI:
10.1128/AAC.02571-13
[Indexed for MEDLINE]
Free PMC Article

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