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Microbes Infect. 2014 Apr;16(4):273-82. doi: 10.1016/j.micinf.2014.01.007. Epub 2014 Feb 8.

Structure and function of toll-like receptor 8.

Author information

1
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
2
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; CREST, JST, Japan. Electronic address: shimizu@mol.f.u-tokyo.ac.jp.

Abstract

Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms.

KEYWORDS:

Innate immunity; Structural biology; Toll-like receptor

PMID:
24513445
DOI:
10.1016/j.micinf.2014.01.007
[Indexed for MEDLINE]

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