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Can J Ophthalmol. 2014 Feb;49(1):60-5. doi: 10.1016/j.jcjo.2013.09.007.

Quantitative echography in primary uveal melanoma treated by proton beam therapy.

Author information

1
Galliera Hospital, Ocular Oncology Center, Genoa University, Genoa, Italy. Electronic address: carlo.mosci@galliera.it.
2
Galliera Hospital, Ocular Oncology Center, Genoa University, Genoa, Italy.
3
Department of Computer and Information Science, Genoa University, Genoa, Italy.

Abstract

OBJECTIVE:

To describe the dynamics of thickness and internal reflectivity after proton beam therapy (PBT) in uveal melanoma.

PARTICIPANTS:

One hundred and ninety-eight consecutive patients with choroidal or ciliary body melanoma treated by PBT were retrospectively considered.

METHODS:

The post-PBT follow-up included ophthalmologic examination, retinography, and B and A modes of standardized echography every 6 months. A total of 1393 examinations were performed. We take into account 4 tumour categories according to the seventh TNM classification.

RESULTS:

Before PBT, tumour thickness ranged from 1.5 to 12.5 mm with a mean of 5.9 mm. Its decrease after radiotherapy was best fitted by the sum of a first-order exponential decay and a constant with a decay half-life of 15 months. Based on the fit, tumour thickness stabilized on a constant value representing, on average, 47% of the initial value. Mean internal reflectivity before PBT was 68%. The dynamics of the reflectivity were best fitted by an exponential and a constant, with rise half-life of 11 months, and stability value of 87%.

CONCLUSIONS:

We found that ultrasonographic dynamics of uveal melanoma treated by PBT resembles a function composed of the sum of a constant and a first-order exponential, as previously noted in studies on brachytherapy. Interestingly, after PBT, because of its shorter half-life, internal reflectivity has a faster dynamic response than thickness in large tumours, suggesting that increase of internal reflectivity is a more sensitive indicator of early response to therapy in larger tumours.

PMID:
24513359
DOI:
10.1016/j.jcjo.2013.09.007
[Indexed for MEDLINE]

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