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Biochim Biophys Acta. 2014 Aug;1843(8):1649-63. doi: 10.1016/j.bbamcr.2014.01.035. Epub 2014 Feb 7.

Assembly and structure of the T3SS.

Author information

1
Department of Biochemistry and Molecular Biology, Center for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
2
Department of Biochemistry and Molecular Biology, Center for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address: ncjs@mail.ubc.ca.

Abstract

The Type III Secretion System (T3SS) is a multi-mega Dalton apparatus assembled from more than twenty components and is found in many species of animal and plant bacterial pathogens. The T3SS creates a contiguous channel through the bacterial and host membranes, allowing injection of specialized bacterial effector proteins directly to the host cell. In this review, we discuss our current understanding of T3SS assembly and structure, as well as highlight structurally characterized Salmonella effectors. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.

KEYWORDS:

Bacterial pathogenesis; Bacterial secretion; Structural biology; Type 3 secretion

PMID:
24512838
DOI:
10.1016/j.bbamcr.2014.01.035
[Indexed for MEDLINE]
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