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Nature. 1988 Mar 31;332(6163):411-5.

A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

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1
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.

Abstract

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

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PMID:
2451132
DOI:
10.1038/332411a0
[Indexed for MEDLINE]
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