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Anticancer Res. 2014 Feb;34(2):1021-5.

Prevalence and expression of human papillomavirus in 53 patients with oral tongue squamous cell carcinoma.

Author information

1
St. Savvas Regional Anticancer Oncology Hospital of Athens, 171 Alexandras Avenue, 11522 Athens, Greece. epanot@tee.gr.

Abstract

BACKGROUND/AIM:

Human papillomavirus (HPV) infection has been considered a potential risk factor for the development of oral tongue squamous cell carcinoma (SCC). The purpose of the present study was to investigate HPV infection and high-risk HPV E6/E7 mRNA expression in SCC of the oral tongue in 53 Greek patients.

MATERIALS AND METHODS:

Fifty-three biopsies were collected from patients with SCC of the oral tongue and tested for HPV DNA and E6/E7 mRNA expression.

RESULTS:

The overall prevalence of HPV DNA was 11.3% (6/53), while high-risk HPV DNA was found in 7.5% (4/53) of SCC of the oral tongue. E6/E7 mRNA expression was observed in 9.4% (5/53) samples examined. HPV 16 was the commonest genotype identified by both DNA and RNA assays. A total of 28.3% (15/53) of the patients were non-smokers and non-drinkers. HPV infection was strongly associated with abstinence from tobacco and alcohol (p=0.013).

CONCLUSION:

The presence of high-risk HPV E6/E7 mRNA expression suggests that HPV may be implicated in the pathogenesis of SCC of the oral tongue.

KEYWORDS:

Greek patients; HPV; oral cavity squamous cell carcinoma; oral tongue squamous cell carcinoma

PMID:
24511049
[Indexed for MEDLINE]
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