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Methods Mol Biol. 2014;1121:309-13. doi: 10.1007/978-1-4614-9632-8_27.

Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates.

Author information

1
Division of Immuno-Virology, CEA, Institute for Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.

Abstract

Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development of human vaccines, using noninvasive needleless electrodes.

PMID:
24510834
DOI:
10.1007/978-1-4614-9632-8_27
[Indexed for MEDLINE]

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