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Transl Stroke Res. 2014 Apr;5(2):174-89. doi: 10.1007/s12975-014-0323-4. Epub 2014 Feb 11.

Subarachnoid hemorrhage: a review of experimental studies on the microcirculation and the neurovascular unit.

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1
Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.

Abstract

Increasingly, experimental research in subarachnoid hemorrhage (SAH) has investigated early brain injury and the microcirculation. A number of pathophysiological changes occur in the cerebral microvessels after SAH including altered vasoreactivity, vasoconstriction, inflammation, blood-brain barrier impairment, increased microthrombi, and inversion of neurovascular coupling. This focused review looks at the current state of knowledge regarding the changes that occur in the microcirculation and the neurovascular unit after SAH.

PMID:
24510780
DOI:
10.1007/s12975-014-0323-4
[Indexed for MEDLINE]
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