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J Surg Oncol. 2014 Mar;109(4):314-9. doi: 10.1002/jso.23554. Epub 2014 Feb 10.

Intralesional therapy with PV-10 (Rose Bengal) for in-transit melanoma.

Author information

1
Department of Surgical Oncology, Melanoma Section, M. D. Anderson Cancer Center, Houston, Texas.

Abstract

Rose Bengal is a novel injectable agent that has been evaluated as a rational treatment strategy for melanoma patients with recurrent unresectable local/regional metastases accessible for intralesional injection. PV-10 (10% Rose Bengal) has completed phase 1 and phase 2 multi-center clinical trials demonstrating significant local/regional disease control and also responses in non-injected regional bystander lesions and distant metastases. The published results of studies that have assessed PV-10 are presented, and the rationale for combining its use with recently approved immunotherapeutic agents is discussed.

KEYWORDS:

intralesional therapy; melanoma; treatment

PMID:
24510477
DOI:
10.1002/jso.23554
[Indexed for MEDLINE]

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