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Nat Rev Microbiol. 2014 Mar;12(3):181-96. doi: 10.1038/nrmicro3199. Epub 2014 Feb 10.

Bacterial transformation: distribution, shared mechanisms and divergent control.

Author information

1
1] Centre National de la Recherche Scientifique, LMGM-UMR5100, F-31000 Toulouse, France. [2] Université de Toulouse, UPS, Laboratoire de Microbiologie et Génétique Moléculaires, F-31000 Toulouse, France.

Abstract

Natural bacterial transformation involves the internalization and chromosomal integration of DNA and has now been documented in ~80 species. Recent advances have established that phylogenetically distant species share conserved uptake and processing proteins but differ in the inducing cues and regulatory mechanisms that are involved. In this Review, we highlight divergent and common principles that govern the transformation process in different bacteria. We discuss how this cumulative knowledge enables the prediction of new transformable species and supports the idea that the main role of internalized DNA is in the generation of genetic diversity or in chromosome repair rather than in nutrition.

PMID:
24509783
DOI:
10.1038/nrmicro3199
[Indexed for MEDLINE]

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