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Nat Rev Microbiol. 2014 Mar;12(3):223-9. doi: 10.1038/nrmicro3217. Epub 2014 Feb 10.

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance.

Author information

1
Queensland Paediatric Infectious Diseases Laboratory and Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, Queensland 4029, Australia.
2
WHO Collaborating Centre for Sexually Transmitted Diseases and HIV, Microbiology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, New South Wales 2031, Australia.
3
Melbourne Sexual Health Centre, Alfred Health, Carlton Victoria 3053, Australia and Melbourne School of Population Health, University of Melbourne, Victoria 3010, Australia.
4
1] Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia. [2] Sydney Sexual Health Centre, Sydney Hospital, Sydney New South Wales 2000, Australia.
5
Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia.
6
Baker IDI Central Australia, Alice Springs, Northern Territory 0870, Australia.
7
1] Queensland Paediatric Infectious Diseases Laboratory and Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, Queensland 4029, Australia. [2] Microbiology Division, Pathology Queensland Central, Royal Brisbane and Women's Hospital Campus, Queensland 4006, Australia.

Abstract

The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.

PMID:
24509781
DOI:
10.1038/nrmicro3217
[Indexed for MEDLINE]

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