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Nat Neurosci. 2014 Mar;17(3):407-15. doi: 10.1038/nn.3647. Epub 2014 Feb 9.

The endocannabinoid system controls food intake via olfactory processes.

Author information

1
1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France. [3].
2
1] Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University and CIBERNED, Madrid, Spain. [2].
3
Department of Neurosciences, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain.
4
1] Laboratory for Perception and Memory, Institut Pasteur, Paris, France. [2] CNRS UMR 3571, Paris, France.
5
CNRS UMR 8165, IMNC, Univ. Paris Diderot & Sud, Orsay, France.
6
Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
7
1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
8
Institut fuer Physiologie I, Westfaelische Wilhelms-Universitaet, Muenster, Germany.
9
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University and CIBERNED, Madrid, Spain.
10
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
11
INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France.
12
1] Department of Neurosciences, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain. [2].

Abstract

Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.

Comment in

PMID:
24509429
DOI:
10.1038/nn.3647
[Indexed for MEDLINE]

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