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Curr Opin Struct Biol. 2014 Apr;25:86-91. doi: 10.1016/ Epub 2014 Feb 5.

Cellular and molecular structure as a unifying framework for whole-cell modeling.

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Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address:


Whole-cell modeling has the potential to play a major role in revolutionizing our understanding of cellular biology over the next few decades. A computational model of the entire cell would allow cellular biologists to integrate data from many disparate sources in a single consistent framework. Such a comprehensive model would be useful both for hypothesis testing and in the discovery of new behaviors that emerge from complex biological networks. Cellular and molecular structure can and should be a key organizing principle in a whole-cell model, connecting models across time and length scales in a multiscale approach. Here I present a summary of recent research centered around using molecular and cellular structure to model the behavior of cells.

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