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Curr Opin Cell Biol. 2014 Apr;27:126-35. doi: 10.1016/j.ceb.2014.01.005. Epub 2014 Feb 6.

Novel insights into G protein and G protein-coupled receptor signaling in cancer.

Author information

1
Oral and Pharyngeal Cancer Branch, Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
2
Oral and Pharyngeal Cancer Branch, Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sg39v@nih.gov.

Abstract

G protein-coupled receptors (GPCRs) play a central role in signal transmission, thereby controlling many facets of cellular function. Overwhelming evidence now implicates GPCRs, G proteins and their downstream signaling targets in cancer initiation and progression, where they can influence aberrant cell growth and survival, largely through activation of AKT/mTOR, MAPKs, and Hippo signaling pathways. GPCRs also play critical roles in the invasion and metastasis of cancer cells via activation of Rho GTPases and cytoskeletal changes, and angiogenesis to supply the tumor with nutrients and provide routes for metastasis. Lastly, GPCRs contribute to the establishment and maintenance of a permissive tumor microenvironment. Understanding GPCR involvement in cancer malignancy may help identify novel therapeutic opportunities for cancer prevention and treatment.

PMID:
24508914
PMCID:
PMC4021379
DOI:
10.1016/j.ceb.2014.01.005
[Indexed for MEDLINE]
Free PMC Article

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