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Cell Metab. 2014 Mar 4;19(3):380-92. doi: 10.1016/j.cmet.2014.01.002. Epub 2014 Feb 6.

Peroxisomes: a nexus for lipid metabolism and cellular signaling.

Author information

1
Division of Endocrinology, Metabolism and Lipid Research; Department of Medicine, Washington University, St. Louis, MO 63110, USA. Electronic address: ilodhi@dom.wustl.edu.
2
Division of Endocrinology, Metabolism and Lipid Research; Department of Medicine, Washington University, St. Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University, St. Louis, MO 63110, USA. Electronic address: csemenko@wustl.edu.

Abstract

Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive oxygen chemical debris discarded by other organelles. However, their functions extend far beyond hydrogen peroxide metabolism. Peroxisomes are intimately associated with lipid droplets and mitochondria, and their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether lipids, may be critical for generating cellular signals required for normal physiology. Here, we review the biology of peroxisomes and their potential relevance to human disorders including cancer, obesity-related diabetes, and degenerative neurologic disease.

PMID:
24508507
PMCID:
PMC3951609
DOI:
10.1016/j.cmet.2014.01.002
[Indexed for MEDLINE]
Free PMC Article

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