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Dev Biol. 2014 May 1;389(1):50-67. doi: 10.1016/j.ydbio.2014.01.023. Epub 2014 Feb 6.

Sensational placodes: neurogenesis in the otic and olfactory systems.

Author information

1
MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK. Electronic address: e.maier@sheffield.ac.uk.
2
Division of Biology and Biological Engineering, MC 139-74, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: saxena@caltech.edu.
3
Laboratory of Developmental Biology, Universitat Pompeu Fabra/PRBB, Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: berta.alsina@upf.edu.
4
Division of Biology and Biological Engineering, MC 139-74, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: mbronner@caltech.edu.
5
MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK. Electronic address: t.whitfield@sheffield.ac.uk.

Abstract

For both the intricate morphogenetic layout of the sensory cells in the ear and the elegantly radial arrangement of the sensory neurons in the nose, numerous signaling molecules and genetic determinants are required in concert to generate these specialized neuronal populations that help connect us to our environment. In this review, we outline many of the proteins and pathways that play essential roles in the differentiation of otic and olfactory neurons and their integration into their non-neuronal support structures. In both cases, well-known signaling pathways together with region-specific factors transform thickened ectodermal placodes into complex sense organs containing numerous, diverse neuronal subtypes. Olfactory and otic placodes, in combination with migratory neural crest stem cells, generate highly specialized subtypes of neuronal cells that sense sound, position and movement in space, odors and pheromones throughout our lives.

KEYWORDS:

Hair cell; Neurogenesis; Olfactory; Otic; Sensory neuron

PMID:
24508480
PMCID:
PMC3988839
DOI:
10.1016/j.ydbio.2014.01.023
[Indexed for MEDLINE]
Free PMC Article

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