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J Emerg Med. 2014 May;46(5):670-9. doi: 10.1016/j.jemermed.2013.08.102. Epub 2014 Feb 6.

A review of methylene blue treatment for cardiovascular collapse.

Author information

1
Department of Toxicology, University of California, San Diego, San Diego, California.

Abstract

BACKGROUND:

Historically, methylene blue (MB) has been used for multiple purposes, including as an antidote for toxin-induced and hereditary methemoglobinemia, ifosfamide-induced encephalopathy, and ackee fruit and cyanide poisoning; as an aniline dye derivative, antimalarial agent, and antidepressant.

DISCUSSION:

Most recently, the use of MB has been advocated as a potential adjunct in the treatment of shock states. Our article reviews the role of MB in septic shock, anaphylactic shock, and toxin-induced shock. MB is proposed to increase blood pressure in these shock states by interfering with guanylate cyclase activity, and preventing cyclic guanosine monophosphate production and vasodilatation.

SUMMARY:

MB may be an adjunct in the treatment of septic shock, anaphylactic shock, and toxin-induced shock.

KEYWORDS:

anaphylactic shock; methylene blue; septic shock; shock due to toxin

Comment in

PMID:
24508113
DOI:
10.1016/j.jemermed.2013.08.102
[Indexed for MEDLINE]

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