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Asian Pac J Trop Med. 2014 Apr;7(4):317-20. doi: 10.1016/S1995-7645(14)60047-X.

Effect of RSCs combined with COP-1 on optic nerve damage in glaucoma rat model.

Author information

1
Department of Ophthalmology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
2
Department of Ophthalmology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. Electronic address: 28906390@qq.com.

Abstract

OBJECTIVE:

To explore effect of retinal stem cells (RSCs) combined with copolymer-1 (COP-1) immunotherapy on optic nerve damage in glaucoma rat model.

METHODS:

A total of 40 SD rats were selected for glaucoma model and were randomly divided into 4 groups to observe protective effects of RSCs transplantation combined with COP-1.

RESULTS:

Brain-derived neurotrophic factor (BDNF) and insulin like growth factor-1 (IGF-1) were either positive in retina of RSCs transplanted or COP-1 immunological treated rat. Positive rate of BDNF and IGF-1 and expression of mRNA and protein were significantly higher in RSCs transplantation combined with COP-1 immunotherapy treated rats compared with the other 3 groups, in which amount of apoptotic RGCs was lowest.

CONCLUSIONS:

RSCs transplantation combined with COP-1 immunotherapy can promote the secretion of BDNF and IGF-1. They protect RGCs in glaucoma rats in coordination, significantly reduce the number of apoptosis RGCs so as to alleviate the optic nerve damage. It ponits a new research direction for treatment of glaucoma.

KEYWORDS:

Glaucoma model; Immunotherapy; Polymer −1; Rat; Retinal stem cells

PMID:
24507684
DOI:
10.1016/S1995-7645(14)60047-X
[Indexed for MEDLINE]
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