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J Neuroimmunol. 2014 Mar 15;268(1-2):50-7. doi: 10.1016/j.jneuroim.2014.01.002. Epub 2014 Jan 15.

Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.

Author information

1
Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.
2
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.
3
Intercell USA, Inc., Gaithersburg, MD 20878, USA.
4
H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.
5
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA; Department of Neurology, University of California, Irvine, CA 92697, USA.
6
Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA. Electronic address: magadjanyan@immed.org.

Abstract

Immunotherapeutic approaches to treating Alzheimer's disease (AD) using vaccination strategies must overcome the obstacle of achieving adequate responses to vaccination in the elderly. Here we demonstrate for the first time that application of the Escherichia coli heat-labile enterotoxin adjuvant-laden immunostimulatory patches (LT-IS) dramatically enhances the onset and magnitude of immune responses to DNA- and protein-based vaccines for Alzheimer's disease following intradermal immunization via gene gun and conventional needles, respectively. Our studies suggest that the immune activation mediated by LT-IS offers improved potency for generating AD-specific vaccination responses that should be investigated as an adjuvant in the clinical arena.

KEYWORDS:

Alzheimer's disease; Epitope vaccine; Immune responses; Immunostimulatory patch

PMID:
24507620
PMCID:
PMC3951952
DOI:
10.1016/j.jneuroim.2014.01.002
[Indexed for MEDLINE]
Free PMC Article
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