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J Fr Ophtalmol. 2014 Feb;37(2):115-24. doi: 10.1016/j.jfo.2013.05.027. Epub 2014 Feb 5.

[Retinoblastoma: preliminary results of national treatment protocol at Casablanca university medical center].

[Article in French]

Author information

1
Service d'ophtalmologie pédiatrique, hôpital du 20-Août-1953, CHU de Casablanca, CHU Ibn Rochd, rue Lahcen Laarjoun, 20100 Casablanca, Maroc. Electronic address: asmaaelkettani@yahoo.fr.
2
Service d'ophtalmologie pédiatrique, hôpital du 20-Août-1953, CHU de Casablanca, CHU Ibn Rochd, rue Lahcen Laarjoun, 20100 Casablanca, Maroc.
3
Service d'oncologie pédiatrique et d'hématologie, hôpital du 20-Août-1953, CHU de Casablanca, CHU Ibn Rochd, rue Lahcen Laarjoun, 20100 Casablanca, Maroc.

Abstract

Retinoblastoma is the most frequent intraocular cancer, affecting almost exclusively children. We report prospective study results assessing the national protocol for retinoblastoma treatment in Morocco. Treatment included, depending on stage and laterality, primary chemotherapy either to facilitate enucleation or to make conservative treatment possible, postoperative chemotherapy, enucleation and conservative treatments such as transpupillary thermotherapy, thermochemotherapy and cryotherapy. Radiation was used in a few cases. Close supervision was performed until the age of 5. The incidence of retinoblastoma within the study period was 18 new cases per year in our department. Observations of 32 children were included in the study: 18 unilateral retinoblastomas (56%) and 14 bilateral retinoblastomas (44%), for a total of 46 eyes. Leucocoria was the most frequent presenting symptom (69%). Buphthalmia or proptosis were present in 47% of cases. The stage of retinoblastoma was V/D or E (Reese-Elsworth/ABC) in 69.5% of cases. Enucleation was necessary for 28 eyes. Transpupillary thermotherapy or thermochemotherapy were used for 13 eyes (11 children) and cryotherapy for 13 eyes (10 children). After an average follow-up period of 52 months, among 32 children, 4 died and 2 abandoned treatment. Ocular salvage rate was 85.7% (12 eyes out of 14, among which 11 without radiation). Retinoblastoma is a genetic tumor, which occurs in two forms: sporadic, always unilateral, and hereditary, often bilateral. The latter is the most challenging case. Current treatment protocols rely primarily on chemotherapy and local treatments. The future is oriented toward purely local treatments such as intra-arterial chemotherapy and intraocular chemotherapy.

KEYWORDS:

Chemotherapy; Chimiothérapie; Conservative treatment; Cryotherapy; Cryothérapie; Enucleation; Retinoblastoma; Rétinoblastome; Thermochemotherapy; Thermochimiothérapie; Thermothérapie transpupillaire; Traitement conservateur; Transpupillary thermotherapy; Énucléation

PMID:
24507074
DOI:
10.1016/j.jfo.2013.05.027
[Indexed for MEDLINE]
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