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Cell Stem Cell. 2014 Feb 6;14(2):133-4. doi: 10.1016/j.stem.2014.01.010.

Turning reactive glia into functional neurons in the brain.

Author information

1
Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA.
2
Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA. Electronic address: zhang@waisman.wisc.edu.

Erratum in

  • Cell Stem Cell. 2014 May 1;14(5):689.

Abstract

Following brain injury, reactive glial cells can create scars that inhibit neural repair responses. In this issue of Cell Stem Cell, Guo et al. report that overexpression of NeuroD1 in vivo can directly reprogram reactive glial cells into glutamatergic and GABAergic neurons that integrate into the host's neural circuitry.

PMID:
24506877
PMCID:
PMC4018986
DOI:
10.1016/j.stem.2014.01.010
[Indexed for MEDLINE]
Free PMC Article
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