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Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.

NAD+ deficiency in age-related mitochondrial dysfunction.

Author information

1
Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA. Electronic address: taprolla@facstaff.wisc.edu.
2
Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.

Abstract

Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.

PMID:
24506863
DOI:
10.1016/j.cmet.2014.01.005
[Indexed for MEDLINE]
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