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Biochim Biophys Acta. 1988 Mar 22;939(1):163-6.

Bupivacaine is an effective potassium channel blocker in heart.

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1
Research Institute, Palo Alto Medical Foundation, CA 94301.

Abstract

The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. The effective concentrations, particularly for IK, are similar to those which depress the sodium conductance. Potassium channel block may thus contribute to bupivacaine's reported cardiotoxicity.

PMID:
2450583
DOI:
10.1016/0005-2736(88)90058-2
[Indexed for MEDLINE]

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