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Feasibility of cell therapy in multiple sclerosis: a systematic review of 83 studies.

Author information

1
Stem Cell Biology Department, Stem Cell Technology Research Center, Tehran, Iran.
2
Division of Laboratory Hematology and Blood Banking, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4
Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands.
5
Hematology Department, Faculty of Medical Science, Tarbiat modares University, Tehran, Iran.
6
Toxicology Research Center, Ahvaz Jundishapur, University of Medical Sciences, Ahvaz, Iran.

Abstract

Multiple Sclerosis is an inflammatory disease of the central nervous system in which T cells experience a second phase of activation, which ultimately leads to axonal demyelination and neurological disability. The recent advances in stem cell therapies may serve as potential treatments for neurological disorders. There are broad types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unprecedented hope in treating many debilitating diseases. In this paper we will review the substantial literature regarding experimental and clinical use of these stem cells and possible mechanisms in the treatment of MS. These results may pave the road for the utilization of stem cells for the treatment of MS.

KEYWORDS:

Hematopoietic stem cells; Human embryonic stem cells; Mesenchymal stem cells; Multiple sclerosis; Neural stem cells; Stem cells therapy

PMID:
24505515
PMCID:
PMC3913133

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