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Adv Mater. 2014 May 21;26(19):3024-34. doi: 10.1002/adma.201304428. Epub 2014 Feb 6.

Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine.

Author information

1
Network of Excellence for Functional Biomaterials (NFB), National University of Ireland Galway, (NUI Galway), Galway, Ireland.

Abstract

MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.

KEYWORDS:

cell-sheet tissue engineering; excluding volume effect; extracellular matrix deposition; macromolecular crowding; macromolecular polydispersity

PMID:
24505025
DOI:
10.1002/adma.201304428
[Indexed for MEDLINE]

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