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Urol Int. 2014;93(2):220-8. doi: 10.1159/000356559. Epub 2014 Feb 6.

A meta-analysis of coffee intake and risk of urolithiasis.

Author information

1
Department of Urology, Zhejiang Provincial People's Hospital Affiliated to Zhejiang University, Hangzhou, P.R. China.

Abstract

OBJECTIVE:

Epidemiologic studies have reported various results relating coffee to urolithiasis. A meta-analysis of cohort and case-control studies was conducted to pool the relative risk (RR) estimates of the association between coffee and urolithiasis.

METHODS:

Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary RR estimates. A dose-response meta-analysis was performed for studies reporting categorical RR estimates for a series of exposure levels.

RESULTS:

A total of 6 studies (2 cohort and 4 case-control studies) on coffee intake were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest coffee consumption (OR = 0.70, 95% confidence interval 0.60-0.82) on the risk of urolithiasis. Coffee exhibited an inverse dose-response relationship with urolithiasis. In stratified analysis, a significant inverse association between coffee and urolithiasis was observed in study design, geographical region and gender subgroup.

CONCLUSIONS:

The overall current literature suggests that coffee intake is associated with a decreased risk of urolithiasis. Further efforts should be made to clarify the underlying biological mechanisms.

PMID:
24503776
DOI:
10.1159/000356559
[Indexed for MEDLINE]

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