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Sleep Med. 2014 Mar;15(3):309-14. doi: 10.1016/j.sleep.2013.08.798. Epub 2014 Jan 8.

Depressive feelings in children with narcolepsy.

Author information

1
Integrative Physiology of Brain Arousal System, CRNL, INSERM-U1028, University Lyon 1, Lyon, France.
2
Université de Lyon, Université Lyon 1, Department of Public Health, Institute of Pharmacy (ISPB), EA4173, F-69373 Lyon, France; Hospices Civils de Lyon, Service de Biostatistique, 162 Avenue Lacassagne, 69424 Lyon Cedex 03, France.
3
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome (CNR Narcolepsie-Hypersomnie), France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Unité des Pathologies du Sommeil, Paris, France.
4
Integrative Physiology of Brain Arousal System, CRNL, INSERM-U1028, University Lyon 1, Lyon, France; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome (CNR Narcolepsie-Hypersomnie), France; Pediatric Sleep Unit, Hôpital Femme Mère Enfant, University Lyon 1, Lyon, France.
5
Service de Psychiatrie Infantile, U502, Hôpital Neurologique, University Lyon 1, Lyon, France.
6
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome (CNR Narcolepsie-Hypersomnie), France; Inserm U1061, Sleep Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, France.
7
Sleep Medicine Advanced Research Group, Division of Clinical Neurology, Clinical Hospital, University of São Paulo School of Medicine, São Paulo SP, Brazil.
8
Child and Adolescent Psychopathology Unit, Salvator Hospital, Public Assistance-Marseille Hospitals, University Aix-Marseille II, Marseille, France.
9
National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome (CNR Narcolepsie-Hypersomnie), France; Centre Pédiatrique des Pathologies du Sommeil, Hôpital Robert Debré, Paris, France.
10
Integrative Physiology of Brain Arousal System, CRNL, INSERM-U1028, University Lyon 1, Lyon, France; National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome (CNR Narcolepsie-Hypersomnie), France; Pediatric Sleep Unit, Hôpital Femme Mère Enfant, University Lyon 1, Lyon, France. Electronic address: Patricia.Franco@chu-lyon.fr.

Abstract

OBJECTIVES:

We aimed to evaluate depressive feelings and their correlations in children and adolescents with narcolepsy collected in national reference centers for narcolepsy.

METHODS:

We compared clinical and sleep characteristics of patients with and without depressive symptoms evaluated on the Children's Depression Inventory (CDI).

RESULTS:

Our study sample included 88 children (44 boys; 44 de novo patients) with a mean age of 11.9 ± 3.1 years at diagnosis (37.5% were aged ⩽ 10 years). Obesity was found in 59% of the sample and cataplexy was present in 80.7%. The DQB1*0602 allele was positive in 93.5% of our sample. There were 25% of children who had clinically depressive feelings (CDI>16), especially girls older than the age of 10 years. Bivariate associations indicated that depressive feelings were associated with fatigue (48%), hyperactivity (31%), insomnia (16%), and excessive daytime sleepiness (EDS) (14-24%). In the multivariate model adjusted for gender and age, only fatigue explained the variability of the depression score.

CONCLUSION:

In our large cohort, high levels of depressive symptoms essentially expressed by fatigue affected 25% of children with narcolepsy. The girls older than 10 years of age were especially vulnerable. The similar prevalence of depressive feelings in treated vs never-treated patients suggests a specific need for diagnosing and managing this symptom in young patients with narcolepsy.

KEYWORDS:

Adolescent; Child; Depression; Fatigue; Narcolepsy; Sleep

PMID:
24503472
DOI:
10.1016/j.sleep.2013.08.798
[Indexed for MEDLINE]
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