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Curr Opin Cell Biol. 2014 Jun;28:16-27. doi: 10.1016/j.ceb.2014.01.003. Epub 2014 Feb 4.

Sizing and shaping the nucleus: mechanisms and significance.

Author information

1
Department of Molecular Biology, University of Wyoming, 1000 East University Avenue, Laramie, WY 82071, USA.
2
Department of Molecular Biology, University of Wyoming, 1000 East University Avenue, Laramie, WY 82071, USA. Electronic address: dlevy1@uwyo.edu.

Abstract

The size and shape of the nucleus are tightly regulated, indicating the physiological significance of proper nuclear morphology, yet the mechanisms and functions of nuclear size and shape regulation remain poorly understood. Correlations between altered nuclear morphology and certain disease states have long been observed, most notably many cancers are diagnosed and staged based on graded increases in nuclear size. Here we review recent studies investigating the mechanisms regulating nuclear size and shape, how mitotic events influence nuclear morphology, and the role of nuclear size and shape in subnuclear chromatin organization and cancer progression.

PMID:
24503411
PMCID:
PMC4061251
DOI:
10.1016/j.ceb.2014.01.003
[Indexed for MEDLINE]
Free PMC Article
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