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Gastroenterol Clin North Am. 2014 Mar;43(1):161-73. doi: 10.1016/j.gtc.2013.11.009. Epub 2013 Dec 27.

Obesity and GERD.

Author information

1
Section of Gastroenterology, Temple University School of Medicine, Philadelphia, PA, USA.
2
Section of Gastroenterology, Temple University School of Medicine, Philadelphia, PA, USA. Electronic address: friedfk@tuhs.temple.edu.

Abstract

Epidemiologic data have demonstrated that obesity is an important risk factor for the development of gastroesophageal reflux disease (GERD). There is also accumulating data that obesity is associated with complications related to longstanding reflux such as erosive esophagitis, Barrett esophagus, and esophageal adenocarcinoma. Central obesity, rather than body mass index, appears to be more closely associated with these complications. Surgical data are confounded by the concomitant repair of prevalent hiatal hernias in many patients.

KEYWORDS:

Adiponectin; Barrett esophagus; Gastroesophageal reflux disease; Leptin; Obesity; Waist-to-hip ratio

PMID:
24503366
PMCID:
PMC3920303
DOI:
10.1016/j.gtc.2013.11.009
[Indexed for MEDLINE]
Free PMC Article

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