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Clin Immunol. 2014 Mar;151(1):1-15. doi: 10.1016/j.clim.2013.12.003. Epub 2013 Dec 14.

Airway epithelial regulation of pulmonary immune homeostasis and inflammation.

Author information

1
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA. Electronic address: tealh@uw.edu.
2
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
3
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
4
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.

Abstract

Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases.

KEYWORDS:

Asthma; Chemokine; Chronic-obstructive pulmonary disease; Epithelium; Host defense; Tight junctions

PMID:
24503171
DOI:
10.1016/j.clim.2013.12.003
[Indexed for MEDLINE]

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