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Toxicol Lett. 2014 Oct 15;230(2):263-70. doi: 10.1016/j.toxlet.2014.01.038. Epub 2014 Feb 3.

Perfluorinated compounds: emerging POPs with potential immunotoxicity.

Author information

1
Laboratory of Toxicology, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Italy. Electronic address: emanuela.corsini@unimi.it.
2
U.S. Environmental Protection Agency/Office of Research and Development/National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA.
3
National Toxicology Program, National Institute of Environmental Health Sciences, NIH, RTP, NC, USA.
4
Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.

Abstract

Perfluorinated compounds (PFCs) have been recognized as an important class of environmental contaminants commonly detected in blood samples of both wildlife and humans. These compounds have been in use for more than 60 years as surface treatment chemicals, polymerization aids, and surfactants. They possess a strong carbon-fluorine bond, which leads to their environmental persistence. There is evidence from both epidemiology and laboratory studies that PFCs may be immunotoxic, affecting both cell-mediated and humoral immunity. Reported effects of PFCs include decreased spleen and thymus weights and cellularity, reduced specific antibody production, reduced survival after influenza infection, and altered cytokine production. Immunosuppression is a critical effect associated with exposure to PFCs, as it has been reported to reduce antibody responses to vaccination in children. Mounting evidence suggests that immunotoxicity in experimental animals can occur at serum concentrations below, within, or just above the reported range for highly exposed humans and wildlife. Considering bioaccumulation and exposure to multiple PFCs, the risk of immunotoxicity for humans and wildlife cannot be discounted. This review will discuss current and recently published work exploring the immunomodulatory effects of PFCs in experimental animals and humans.

KEYWORDS:

Cytokine; Immunosuppression; PPAR-α receptor; Perfluorinated compounds; Vaccination

PMID:
24503008
PMCID:
PMC4439925
DOI:
10.1016/j.toxlet.2014.01.038
[Indexed for MEDLINE]
Free PMC Article
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