Gusperimus: immunological mechanism and clinical applications

Rheumatology (Oxford). 2014 Oct;53(10):1732-41. doi: 10.1093/rheumatology/ket451. Epub 2014 Feb 5.

Abstract

Gusperimus is an immunosuppressive drug with a unique mode of action. We review its effects on different arms of the immune system and the current evidence for clinical applications, particularly in the treatment of transplant rejection and ANCA-associated vasculitis.

Keywords: deoxyspergualin; glomerulonephritis; gusperimus; immune suppressant; rejection; systemic lupus erythematosus; transplantation; vasculitis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy*
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology
  • Graft Rejection / drug therapy*
  • Graft Rejection / immunology
  • Guanidines / pharmacology
  • Guanidines / therapeutic use*
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*

Substances

  • Guanidines
  • Immunosuppressive Agents
  • gusperimus