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Head Neck. 2015 Jan;37(1):30-6. doi: 10.1002/hed.23546. Epub 2014 Feb 6.

Correlation of β-catenin, but not PIN1 and cyclin D1, overexpression with disease-free and overall survival in patients with cancer of the parotid gland.

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1
Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.

Abstract

BACKGROUND:

Malignant tumors of the salivary glands comprise about 3% to 5% of all head and neck carcinomas. The purpose of our study was to find possible predictive and/or prognostic markers for parotid cancer.

METHODS:

A total of 46 tissue samples of carcinomas of the parotid gland were immunohistochemically stained for ß-catenin, cyclin D1, and PIN1. The factors were analyzed regarding their prognostic value for disease-free and overall survival.

RESULTS:

An overexpression of the cytoplasmatic ß-catenin was linked to a statistically significant worse outcome regarding disease-free (p = .0296) and overall survival (p = .0416). The 5-year overall survival was 83.9% in patients without and 0% in patients presenting with overexpression of cytoplasmatic ß-catenin. Additionally, Union Internationale Contre le Cancer (UICC) stage correlated with overall survival (p = .0306) and disease-free survival (DFS; p = .0473).

CONCLUSION:

Multivariate analysis showed that overexpression of cytoplasmatic ß-catenin and the UICC stage are 2 independent prognostic markers for survival in patients with parotid cancer.

KEYWORDS:

Cyclin D1; PIN1; parotid cancer; salivary gland cancer; ß-catenin

PMID:
24500803
DOI:
10.1002/hed.23546
[Indexed for MEDLINE]
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