Send to

Choose Destination
Eur J Nutr. 2014 Oct;53(7):1581-90. doi: 10.1007/s00394-014-0664-5. Epub 2014 Feb 6.

Egg consumption and risk of GI neoplasms: dose-response meta-analysis and systematic review.

Author information

The Whiteley-Martin Research Centre, The Discipline of Surgery, Sydney Medical School, Nepean Hospital, The University of Sydney, Level 5, South Block, Penrith, NSW, 2751, Australia.



Previous epidemiological studies on egg consumption and the risk of gastrointestinal (GI) neoplasms suggest a positive association; however, data are limited and the evidence remains controversial. This study aims to investigate and quantify the potential dose-response relationship with an evaluation of cancer site-specific differences.


Relevant studies were identified after the literature search via electronic databases until January 2014. Subgroup analysis for serving portions was performed using two standardized classification methods: (1) less than 3, or 3 or more eggs per week; (2) less than 3, 3-5, or more than 5 eggs per week. Method two excludes studies that only reported consumption frequency. Pooled adjusted odds ratios (ORs) comparing highest and lowest categories of dietary pattern scores were calculated using a random-effects model.


Thirty-seven case-control and seven cohort studies were included for meta-analysis, which contained a total of 424,867 participants and 18,852 GI neoplasm cases. The combined odds ratio (OR) was calculated to 1.15 (95% CI 1.09-1.22; p value heterogeneity <0.001), showing only a slight increase in risk. The correlation was stronger for colon cancers 1.29 (95% CI 1.14-1.46; p value heterogeneity <0.22). Dose-response analysis revealed similar results with stratification methods, and the ORs for an intake of <3 and ≥3 eggs per week were 1.14 (95% CI 1.07-1.22; p value heterogeneity = 0.38) and 1.25 (95% CI 1.14-1.38; p value heterogeneity = 0.25), respectively. With method 2, the ORs for an intake of <3, 3-5, and >5 eggs per week were 1.13 (95% CI 1.06-1.21; p value heterogeneity = 0.25), 1.14 (95% CI 1.01-1.29; p value heterogeneity = 0.06), and 1.19 (95% CI 1.01-1.39; p value heterogeneity <0.001), respectively.


This study provides evidence that egg consumption is associated with a positive dose-response association with the development of GI neoplasms.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center