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Proc Biol Sci. 2014 Feb 5;281(1779):20132673. doi: 10.1098/rspb.2013.2673. Print 2014 Mar 22.

Insulin signalling underlies both plasticity and divergence of a reproductive trait in Drosophila.

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Department of Molecular and Cellular Biology, Harvard University, , 16 Divinity Avenue, Cambridge, MA 02138, USA, Department of Organismic and Evolutionary Biology, Harvard University, , 16 Divinity Avenue, Cambridge, MA 02138, USA.


Phenotypic plasticity is the ability of a single genotype to yield distinct phenotypes in different environments. The molecular mechanisms linking phenotypic plasticity to the evolution of heritable diversification, however, are largely unknown. Here, we show that insulin/insulin-like growth factor signalling (IIS) underlies both phenotypic plasticity and evolutionary diversification of ovariole number, a quantitative reproductive trait, in Drosophila. IIS activity levels and sensitivity have diverged between species, leading to both species-specific ovariole number and species-specific nutritional plasticity in ovariole number. Plastic range of ovariole number correlates with ecological niche, suggesting that the degree of nutritional plasticity may be an adaptive trait. This demonstrates that a plastic response conserved across animals can underlie the evolution of morphological diversity, underscoring the potential pervasiveness of plasticity as an evolutionary mechanism.


Drosophila erecta; Drosophila sechellia; insulin receptor; ovariole; ovary; phenotypic plasticity

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