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Org Lett. 2014 Feb 21;16(4):1128-31. doi: 10.1021/ol403739w. Epub 2014 Feb 5.

Silver-mediated radical aryltrifluoromethylthiolaton of activated alkenes.

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  • 1Department of Chemistry, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.

Abstract

The first example of silver-mediated oxidative aryltrifluoromethylthiolation of activated alkenes to produce valuable trifluoromethylthiole-containing oxindoles was developed. Mechanistic investigations indicated that this novel transformation proceeded through a unique F3CS(•) radical addition path, thus providing a practical and easy-handling method to generate a F3CS(•) radical in the laboratory.

PMID:
24499437
DOI:
10.1021/ol403739w
[PubMed]
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