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Annu Rev Immunol. 2014;32:579-608. doi: 10.1146/annurev-immunol-032712-095941. Epub 2014 Feb 5.

Antigen presentation in the autoimmune diabetes of the NOD mouse.

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Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110; email:


This paper reviews the presentation of peptides by major histocompatibility complex (MHC) class II molecules in the autoimmune diabetes of the nonobese diabetic (NOD) mouse. Islets of Langerhans contain antigen-presenting cells that capture the proteins and peptides of the beta cells' secretory granules. Peptides bound to I-A(g7), the unique MHC class II molecule of NOD mice, are presented in islets and in pancreatic lymph nodes. The various beta cell-derived peptides interact with selected CD4 T cells to cause inflammation and beta cell demise. Many autoreactive T cells are found in NOD mice, but not all have a major role in the initiation of the autoimmune process. I emphasize here the evidence pointing to insulin autoreactivity as a seminal component in the diabetogenic process.

[Indexed for MEDLINE]

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