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Oncoimmunology. 2013 Dec 1;2(12):e26663. Epub 2013 Oct 22.

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma.

Author information

1
Department of Molecular Medicine; Instituto Pasteur-Fondazione Cenci Bolognetti; Sapienza University of Rome; Rome, Italy.

Abstract

Malignant cells constitutively express Natural killer group 2, member D (NKG2D) or DNAX Accessory Molecule-1 (DNAM-1) ligands, yet they are often unable to trigger a robust cytotoxic cell response. It may be therapeutically useful to implement strategies aimed at increasing the density of NKG2D and DNAM-1 ligands on the surface of cancer cells, endowing them with the capacity to activate potent antitumor natural killer-cell responses.

KEYWORDS:

DNAM-1; NK cells; NKG2D; multiple myeloma; tumor immunology

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