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Br J Cancer. 2014 Mar 4;110(5):1334-7. doi: 10.1038/bjc.2014.38. Epub 2014 Feb 4.

Effect of oral anticoagulants on the outcome of faecal immunochemical test.

Collaborators (187)

Bujanda L, Alkiza ME, Altzibar J, Artiñano E, Cosme A, Egitegi I, Elorriaga K, Elósegui JL, Enriquez-Navascués JM, Erce C, Gutiérrez-Stampa MA, Herreros-Villanueva M, Hijona E, Jaúregui M, Laredo E, Martínez R, Mitxelena MJ, Montalvo I, Placer C, Portillo I, Cubiella J, Aguado MB, Aldecoa S, Alonso A, Castro I, Cid E, Cid L, Clofent J, de Castro ML, Estévez P, González MD, González S, González-Mao MC, Hernández V, Iglesias B, Iglesias F, Iglesias P, Martínez ÁL, Macenlle R, Martínez A, Martínez D, Menéndez C, Méndez C, Hermo JA, Pérez I, Portasany C, Rionda M, Rivera C, Rodríguez B, Rodríguez R, Rubio M, Vázquez M, Vázquez JÁ, Vega P, Vidal MC, Zubizarreta R, Salas D, Andrés M, Calvo C, Jimenez M, Málaga A, Perez E, Peris A, Ponce M, Sala T, Teruel G, Lanas A, Gonzalez-Rubio F, Moya-Calvo A, Polo-Tomas M, Roncales MP, Sebastian-Martínez P, Valencia-Doblas MÁ, Valero-Capilla N, Andreu M, Álvarez C, Augé JM, Balaguer F, Barau M, Bessa X, Bory F, Burón A, Castells A, Castells X, Comas M, Cuatrecasas M, Estrada M, Ferrer O, Garrell I, Grau J, Guayta R, Hernández C, López-Cerón M, Macià F, Moreira L, Ocaña T, Pellisé M, Piracés M, Polbach S, Puigvehí M, Rodríguez C, Sala M, Seoane A, Serradesanferm A, Sivilla J, Carballo F, Alajarín M, Alberca F, Bermejo J, Carrillo J, Cruzado J, López P, Martínez M, Navarro MD, Ono A, Parra S, Pérez-Riquelme F, Riquelme P, Quintero E, Alarcón O, Arteaga V, Carrillo-Palau M, Díez-Fuentes ML, Gimeno-García AZ, González-Méndez Y, Hernández-Guerra M, Linertová R, Nicolás-Pérez D, Pérez-Cánovas ME, Rodríguez-Quintana M, Romero-García R, Morillas JD, Abreu L, Amador FJ, Arroyo M, Bandrés F, Barba M, Blanco JM, Cacho G, Cantero J, Carrasco J, Castellano G, Colina F, Chaparro M, Díaz-Rubio M, Díaz-Tasende J, Esteban JM, Fernández C, Fernández-Díez S, Gil MF, Ferrándiz J, Franco A, García-Álvarez G, Garrido A, Garrido S, Gisbert JP, Gómez-Haba M, Gómez-Molíns I, González-Navarro A, González MJ, Herranz B, Herránz P, Herreros A, Iglesias R, Izquierdo S, López C, López-Rubio MA, Marín A, Marín JC, Martín MC, Martínez JL, Martínez R, Moliner C, Moreno JM, Moreno R, Nogueiras A, Pérez MT, Píriz R, Plaza C, Polentinos E, Poves C, Ruíz P, Salces I, Sánchez-Ceballos F, Santander C, Sastre R, Valentín V.

Author information

1
Department of Gastroenterology, Hospital Universitario Donostia, Instituto Biodonostia, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.
2
Hospital Universitario Donostia, Instituto Biodonostia, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), San Sebastián, Spain.
3
Department of Gastroenterology, University of Zaragoza, IIS Aragón, CIBERehd, Zaragoza, Spain.
4
Department of Gastroenterology, Hospital Universitario de Canarias, Universidad de La Laguna, Tenerife, Spain.
5
Department of Gastroenterology, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
6
Servicio de Aparato Digestivo, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
7
Department of Gastroenterology, Hospital Clínico San Carlos, Madrid, Spain.
8
Department of Gastroenterology, Hospital Fundación Alcorcón, Madrid, Spain.
9
Programa de Cribado de Cáncer Colorrectal, Dirección General de Salud Pública, Conselleria de Sanitat, Valencia, Spain.
10
Department of Gastroenterology, Hospital del Mar, IMIM, Barcelona, Catalonia, Spain.
11
Unidad de Gestión Clínica de Digestivo, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
12
Centro Coordinador del Programa de Cribado Cáncer Colorrectal, Organización Central de Osakidetza-Servicio Vasco de Salud, Bilbao, Spain.
13
Department of Gastroenterology, Hospital General Universitario de Alicante, Alicante, Spain.
14
Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain.

Abstract

BACKGROUND:

We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.

METHODS:

Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml(-1)) between November 2008 and June 2011.

RESULTS:

Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P=0.4).

CONCLUSIONS:

Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

PMID:
24496455
PMCID:
PMC3950875
DOI:
10.1038/bjc.2014.38
[Indexed for MEDLINE]
Free PMC Article

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