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Braz Dent Sci. 2013 Apr 1;16(2):31-36.

Effects of typified propolis on mutans streptococci and lactobacilli: a randomized clinical trial.

Author information

1
Biomaterials Research Group - School of Dentistry - UNIBAN Bandeirante Anhanguera University - São Paulo - SP - Brazil.
2
Professional Masters Program in Pharmacy - School of Pharmacy - UNIBAN Bandeirante Anhanguera University - São Paulo - SP - Brazil.
3
Microbiology Research Group - Professional Masters Program in Pharmacy - UNIBAN Bandeirante Anhanguera University - São Paulo - SP - Brazil.
4
Department of Cariology & Comprehensive Care - College of Dentistry - New York University - New York-NY - USA.

Abstract

OBJECTIVE:

The aim of this study was to determine in a randomized, double-blind, placebo-controlled clinical trial the effects of typified propolis and chlorhexidine rinses on salivary levels of mutans streptococci (MS) and lactobacilli (LACT).

METHODS:

One hundred patients were screened for salivary levels of MS >100,000 CFUs/mL of saliva. All patients presented with at least one cavitated decayed surface. Sixty patients met entry criteria. Subjects were adults 18-55 years old. After restoration of cavitated lesions patients were randomized to 3 experimental groups: 1) PROP-alcohol-free 2% typified propolis rinse (n = 20); 2) CHX- 0.12% chlorhexidine rinse; 3) PL-placebo mouthrinse. Patients rinsed unsupervised 15 mL of respective rinses twice a day for 1 min for 28 days. Patients were assessed for the salivary levels of MS (Dentocult SM) and LACT (Dentocult LB) at baseline, 7-day, 14-day, and at 28-day visits (experimental effects) and at 45-day visit (residual effects). General linear models were employed to analyze the data.

RESULTS:

PROP was superior to CHX at 14-day and 28-day visits in suppressing the salivary levels of MS (p < .05). PROP was superior to PL at all visits (p < .01). The residual effects of PROP in suppressing the salivary levels of MS could still be observed at the 45-day visit, where significant differences between PROP and CHX (p < .05), were demonstrated. PROP was significantly superior than CHX in suppressing the levels of salivary LACT at the 28-day visit (p < .05).

CONCLUSION:

Typified propolis rinse was effective in suppressing cariogenic infections in caries-active patients when compared to existing and placebo therapies.

KEYWORDS:

Chlorhexidine; Lactobacilli; Mutans Streptococci; Randomized clinical trial; Typified propolis

PMID:
24494174
PMCID:
PMC3909523

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