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JPEN J Parenter Enteral Nutr. 2015 Jul;39(5):552-61. doi: 10.1177/0148607114520993. Epub 2014 Feb 3.

Whey Peptide-Based Formulas With ω-3 Fatty Acids Are Protective in Lipopolysaccharide-Mediated Sepsis.

Author information

1
Department of Nutrition, University of Tokushima Graduate School, Tokushima, Japan.
2
Department of Anesthesiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
3
Department of Anesthesiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan tsutsumi@tokushima-u.ac.jp.

Abstract

BACKGROUND:

Sepsis and septic shock syndrome are among the leading causes of death in critically ill patients. Lipopolysaccharide (LPS) released by bacteria within the colon may translocate across a compromised epithelium, leading to oxidative stress, inflammation, sepsis, and eventually death.

METHODS:

We examined the effects of a whey-based enteral formula high in cysteine (antioxidant precursor) and the addition of ω-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), against a mouse model of LPS-induced sepsis. Mice were fed either a whey-based diet with EPA-DHA (PAF), a whey-based diet without EPA-DHA (PSTD), or a casein-based control diet (CONT).

RESULTS:

Mice fed PAF or PSTD were protected against LPS-induced weight loss. Whey-based diets suppressed inflammatory cytokine release and oxidative stress damage. Furthermore, PAF and PSTD were able to inhibit autophagy, a mechanism in which the cell recycles damaged organelles. These anti-inflammatory and antioxidative effects of PSTD and PAF resulted in decreased liver inflammation and intestinal damage and promoted protective microbiota within the intestines.

CONCLUSIONS:

These data suggest a clinical role for whey peptide-based diets in promoting healing and recovery in critically ill patients.

KEYWORDS:

antioxidants; critical care; enteral formulas; lipopolysaccharide; sepsis; whey peptide

PMID:
24492312
DOI:
10.1177/0148607114520993
[Indexed for MEDLINE]
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