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Obstet Gynecol Clin North Am. 2014 Mar;41(1):133-44. doi: 10.1016/j.ogc.2013.10.005. Epub 2013 Dec 10.

Inherited thrombophilias and adverse pregnancy outcomes: a review of screening patterns and recommendations.

Author information

1
Department of Obstetrics and Gynecology, University of Vermont, 89 Beaumont Avenue, Given C262, Burlington, VT 05406, USA.
2
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Fertility Associates of Memphis, 80 Humphreys Center, Suite 307, Memphis, TN 38120, USA. Electronic address: wkutteh@fertilitymemphis.com.

Abstract

Historically, much controversy has existed regarding the association of inherited thrombophilias with adverse pregnancy outcomes. The current guidelines do not recommend screening unless a personal history of venous thromboembolism is present, but the authors' survey of physician screening patterns has suggested that up to 40% of physicians may screen contrary to the current guidelines. This article summarizes the existing evidence for each inherited thrombophilia and reviews the current guidelines.

KEYWORDS:

Inherited thrombophilias; Intrauterine growth restriction; OB/GYN; Placental abruption; Preeclampsia; Pregnancy; Recurrent pregnancy loss

PMID:
24491988
DOI:
10.1016/j.ogc.2013.10.005
[Indexed for MEDLINE]

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