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Int J Vitam Nutr Res. 2013;83(2):101-11. doi: 10.1024/0300-9831/a000149.

Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy: a meta-analysis of randomized controlled trials.

Author information

1
Department of Clinical Pharmacy, College of Pharmacy, Seoul National University, South Korea.
2
College of Pharmacy, Yonsei University, Gyeonggi-do, South Korea.
3
Department of Family Medicine, Seoul National University Hospital, South Korea.
4
College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Gyeonggi-do, South Korea.

Abstract

PURPOSE:

This study aimed to investigate the neuroprotective effects of vitamin E for preventing chemotherapy-induced peripheral neuropathy (CIPN).

METHODS:

A comprehensive search from 1973 through July 2011 identified randomized controlled trials (RCTs) that reported the preventive effects of vitamin E on CIPN. The relative risk (RR) of CIPN with vitamin E supplementation, compared with placebo, was assessed with the Bayesian random effect model and expressed as RR with a 95 % credible-interval (CrI). Bayesian outcome probabilities were calculated as the probability (P) of RR < 1.

RESULTS:

Five RCTs, involving 319 patients, were identified. Upon pooling these RCTs, vitamin E supplementation (300 - 600 mg/day) had a significant effect on CIPN prevention (RR 0.43; 95 % CrI 0.10 - 1.00, P = 97.5 %). Subgroup analysis by chemotherapeutic agent type was only available for cisplatin and showed that vitamin E supplementation significantly reduced the incidence of CIPN (RR 0.26; 95 % CrI 0.06 - 0.89, P = 98.1 %). Furthermore, there were no adverse effects caused by vitamin E supplementation in any of the RCTs.

CONCLUSION:

Available data included in this meta-analysis show that vitamin E supplementation might significantly prevent CIPN. Currently, however, the data are insufficient to confidently conclude the true value. Large-scale, rigorously designed RCTs are needed to confirm the role of vitamin E supplementation in CIPN prevention.

KEYWORDS:

chemotherapy; peripheral neuropathy; vitamin E

PMID:
24491883
DOI:
10.1024/0300-9831/a000149
[Indexed for MEDLINE]
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