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Anesthesiol Clin. 2014 Mar;32(1):133-55. doi: 10.1016/j.anclin.2013.10.003. Epub 2013 Dec 8.

Anesthetic neurotoxicity.

Author information

1
Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 2001, Cincinnati, OH 45229, USA. Electronic address: erica.lin@cchmc.org.
2
Department of Anesthesiology, Perioperative, and Pain Medicine, Harvard Medical School, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA.
3
Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 2001, Cincinnati, OH 45229, USA.

Abstract

All routinely utilized sedatives and anesthetics have been found neurotoxic in a wide variety of animal species, including non-human primates. Neurotoxic effects observed in animals include histologic evidence for apoptotic neuronal cell death and subsequent learning and memory impairment. Several cohort studies in neonates with significant comorbidities requiring surgical procedures early in life have also demonstrated abnormal neurodevelopmental outcomes. This article provides an overview of the currently available data from both animal experiments and human clinical studies regarding the effects of sedatives and anesthetics on the developing brain.

KEYWORDS:

Anesthesia; Anesthetics; Infant; Learning impairment; Neurodegeneration; Neurotoxicity

PMID:
24491654
DOI:
10.1016/j.anclin.2013.10.003
[Indexed for MEDLINE]

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