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Head Neck. 2014 Dec;36(12):1783-8. doi: 10.1002/hed.23539. Epub 2014 Feb 1.

Matrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinoma.

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1
Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.

Abstract

BACKGROUND:

Predicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 and MMP-25 in oral tongue SCC.

METHODS:

We used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP-7 and MMP-25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data.

RESULTS:

Immunohistochemistry revealed MMP-7 and MMP-25 expression in 90% (n = 63 of 70) and 90% (n = 64 of 71) of the tumors, respectively. MMP-7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP-7 expression was predictive for poor outcome (p = .021). Immunostaining of MMP-25 did not correlate with any clinical parameters.

CONCLUSION:

We conclude that MMP-7, but not MMP-25, expression may have prognostic significance in early-stage oral tongue SCC.

KEYWORDS:

biomarker; immunohistochemistry; matrix metalloproteinase; oral cancer; prognosis

PMID:
24488688
DOI:
10.1002/hed.23539
[Indexed for MEDLINE]
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