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Brain Topogr. 2015 Sep;28(5):702-709. doi: 10.1007/s10548-014-0353-y. Epub 2014 Feb 1.

Cortical Thickness Changes Associated with Photoparoxysmal Response.

Author information

1
Clinic of Neurology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.
2
Department of Neurology and Neurosurgery, National Scientifico-Practical Centre of Emergency Medicine, Medical and Pharmaceutical University Nicolae Testemiţanu, Chişinău, Moldova.
3
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital of Hvidovre, Hvidovre, Denmark.
4
Institute of Neurology, Psychiatry and Senses, University of Copenhagen, Copenhagen, Denmark.
5
Clinic of Neuropediatrics, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany.
6
Clinic of Neurology, University Hospital Schleswig-Holstein, University of Kiel, Kiel, Germany. s.groppa@neurologie.uni-kiel.de.

Abstract

Photoparoxysmal response (PPR) is an EEG trait of spike and spike-wave discharges in response to photic stimulation that is closely linked to idiopathic generalized epilepsy (IGE). In our previous studies we showed that PPR is associated with functional alterations in the occipital and frontal cortices. The aim of the present study was to determine structural changes associated with PPR. For this purpose we analysed the cortical thickness as derived from T1 MRI images in PPR-positive-subjects (n = 12; 15.5 ± 8.6 years; 4 males), PPR-positive-IGE-patients (n = 12; 14.9 ± 2.7 years; 4 males) and compared these groups with a group of PPR-negative-healthy-controls (HC, n = 17; 15.3 ± 3.6 years; 6 males). Our results revealed an increase of cortical thickness in the occipital, frontal and parietal cortices bilaterally in PPR-positive-subjects in comparison to HC. Moreover PPR-positive-subjects presented a significant decrease of cortical thickness in the temporal cortex in the same group contrast. IGE patients exhibited lower cortical thickness in the temporal lobe bilaterally and in the right paracentral region in comparison to PPR-positive-subjects. Our study demonstrates structural changes in the occipital lobe, frontoparietal regions and temporal lobe, which also show functional changes associated with PPR. Patients with epilepsy present changes in the temporal lobe and supplementary motor area.

PMID:
24487625
DOI:
10.1007/s10548-014-0353-y
[Indexed for MEDLINE]

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