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Kidney Int. 2014 Feb;85(2):236-7. doi: 10.1038/ki.2013.371.

The importance of quantifying genetic heterogeneity in ADPKD.

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1
Emory University School of Medicine, Atlanta, Georgia, USA.

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. New data from Paul et al. suggest that mutations in the PKD1 and PKD2 genes may account for all cases of ADPKD. Further improvements in mutation detection methodologies are needed to determine the true relative frequency of PKD1 versus PKD2 as well as to establish the value of mutation type and location to predict disease severity in this disorder.

PMID:
24487363
PMCID:
PMC3914150
DOI:
10.1038/ki.2013.371
[Indexed for MEDLINE]
Free PMC Article
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