Format

Send to

Choose Destination
See comment in PubMed Commons below
Mech Ageing Dev. 2014 Jun;138:53-8. doi: 10.1016/j.mad.2014.01.007. Epub 2014 Jan 31.

Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase.

Author information

1
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, China.
2
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical College, Zhanjiang, China.
3
Institute of Aging Research, Guangdong Medical College, Dongguan, China.
4
Department of Pathology, University of Washington, Seattle, USA.
5
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Buck Institute for Research on Aging, Novato, USA.
6
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, USA.
7
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
8
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Department of Pathology, University of Washington, Seattle, USA.
9
Institute of Aging Research, Guangdong Medical College, Dongguan, China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, China; Institute of Biochemistry & Molecular Biology, Guangdong Medical College, Zhanjiang, China. Electronic address: xgliu64@126.com.

Abstract

Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.

KEYWORDS:

Lifespan; Mitochondrial superoxide dismutase; Nar1

PMID:
24486555
DOI:
10.1016/j.mad.2014.01.007
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center