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FEBS Lett. 2014 Apr 17;588(8):1221-9. doi: 10.1016/j.febslet.2014.01.031. Epub 2014 Jan 30.

Degradation of connexins and gap junctions.

Author information

1
Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D-218, Bethlehem, PA 18015, USA. Electronic address: mmf4@lehigh.edu.
2
Department of Biological Sciences, Lehigh University, 111 Research Drive, Iacocca Hall, D-218, Bethlehem, PA 18015, USA.
3
Department of Pediatrics, University of Chicago, 900 East 57th St., KCBD, Room 5150, Chicago, IL 60637, USA. Electronic address: vberthou@peds.bsd.uchicago.edu.

Abstract

Connexin proteins are short-lived within the cell, whether present in the secretory pathway or in gap junction plaques. Their levels can be modulated by their rate of degradation. Connexins, at different stages of assembly, are degraded through the proteasomal, endo-/lysosomal, and phago-/lysosomal pathways. In this review, we summarize the current knowledge about connexin and gap junction degradation including the signals and protein-protein interactions that participate in their targeting for degradation.

KEYWORDS:

Autophagosome; Connexin; Gap junction; Lysosome; Proteasome; Ubiquitin

PMID:
24486527
PMCID:
PMC3989500
DOI:
10.1016/j.febslet.2014.01.031
[Indexed for MEDLINE]
Free PMC Article

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